Article

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

2021-01-31

Abstract excerpt

PAX5 is the master transcription factor controlling B cell identity. In humans, mutations in PAX5 account for 30% of B cell acute lymphoblastic leukemia (B-ALL) cases. Investigating the causal effects of PAX5 mutations has however been difficult due to the premature lethality of Pax5 −/− mice. Here we describe a novel mouse strain with a premature STOP mutation in Pax5 (Y351*) that produces a truncated protein...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f6ee948-49d1-5309-ba5b-f4d5d3d14fa2
DOI: 10.1101/2021.01.29.428877

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in miceDOI 10.1101/2021.01.29.428877Read

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read

The <i>Pax-5</i> Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer DiseaseSemantic proximity Read

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemiaSemantic proximity Read

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in miceSemantic proximity Read

GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.Semantic proximity Read

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.Semantic proximity Read

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemiaSemantic proximity Read

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.Semantic proximity Read

The regulation of the B‐cell gene expression programme by Pax5Semantic proximity Read

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.Semantic proximity Read

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemiaSemantic proximity Read

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Semantic proximity Read