Article

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

2020-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we found that increased expression and abundance of the ubiquitin ligase RNF5 contributes to AML development and survival. High RNF5 expression in AML patients correlated with poor prognosis. RNF5 inhibition decreased AML cell growth in culture and in vivo , and blocked development of...

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Literature Corpus work: 1f70fb5a-1c73-5297-b3f0-27203681108a
DOI: 10.1101/2020.10.25.349241

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