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Article

The LRF transcription factor regulates mature B cell development and the germinal center response in mice

6 Jun 2011

Abstract excerpt

B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell-specific conditional knockout mice, we have...

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PMID: 21646720
DOI: 10.1172/jci45682

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