Article
UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
Blood - 16 Jul 2020
Swenson Samantha A, Gilbreath Tyler J, Vahle Heather, Hynes-Smith R Willow, Graham Jared H, Law Henry C-H, Amador Catalina, Woods Nicholas T, Green Michael R, Buckley Shannon M
Abstract excerpt
Coordination of a number of molecular mechanisms including transcription, alternative splicing, and class switch recombination are required to facilitate development, activation, and survival of B cells. Disruption of these pathways can result in malignant transformation. Recently, next-generation sequencing has identified a number of novel mutations in mantle cell lymphoma (MCL) patients including mutations in...
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