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Article

The <i>Pax-5</i> Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease

1 Dec 2011

Abstract excerpt

The Pax-5 oncogene encodes a potent transcription factor that plays a key role in B-cell development and cancerous processes. In normal B-lymphopoiesis, Pax-5 accomplishes a dual function by activating B-cell commitment genes while concomitantly repressing non-B-lineage genes. Given the pivotal importance of Pax-5-mediated processes in B-cell development, an aberrant regulation of Pax5 expression has consistently...

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PMID: 22127921
DOI: 10.1158/0008-5472.can-11-1874

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