Article

Quantifying selection in immune receptor repertoires

2014-04-21

Abstract excerpt

The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors with self and foreign antigenic peptides. To quantify the effect of...

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Literature Corpus work: 7d9e8935-a797-5e8b-8335-89d1b103cac9
DOI: 10.1101/004341

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