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Article

A multi-ethnic reference map of T cell receptor germline diversity reveals evidence of natural selection on alpha chain genes.

Nature communications - 6 Jun 2026

Mantena Sreekar, Edahiro Ryuya, Okada Yukinori, Akbari Ali, Raychaudhuri Soumya

Abstract excerpt

T cell receptors (TCR) orchestrate adaptive immunity, yet the complex, repetitive architecture of the TCR loci has impeded systematic characterization of human genetic variation in the genes encoding the TCR. Using public long-read sequencing data from the Human Pangenome Reference Consortium and All of Us consortia spanning 2719 donors, we build a near-complete map of common alleles in TCR V, D, and J genes,...

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Share to Alleles
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Receptors, Antigen, T-Cell

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Selection, Genetic

Share to T-Lymphocytes

Source

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Identifiers

PMID: 42251052
DOI: 10.1038/s41467-026-73730-9
PMCID: PMC13396459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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