Article

TCR germline diversity reveals evidence of natural selection on variable and joining alpha chain genes

2025-08-24

Abstract excerpt

T cell receptors (TCRs) orchestrate adaptive immunity, yet the complex, repetitive architecture of the TCR loci has impeded systematic characterization of human genetic variation in the genes encoding the TCR. Using public long-read sequencing data from 2,668 donors, we build a near-complete map of common alleles in TCR V, D, and J genes, revealing amino acid variation at almost every position within V genes. We d...

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Literature Corpus work: beb125d8-6efe-5287-813d-d95fb96481c1
DOI: 10.1101/2025.08.20.671277

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