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Article

High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities.

Briefings in bioinformatics - 20 Jul 2018

Heather James M, Ismail Mazlina, Oakes Theres, Chain Benny

Abstract excerpt

T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination. Massively parallel high-throughput sequencing allows millions of different T-cell receptor genes to be characterized from a single sample of blood or tissue. However, the extraordinary heterogeneity of the immune repertoire poses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 28077404
DOI: 10.1093/bib/bbw138
PMCID: PMC6054146

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