Article
Conserved variation: identifying patterns of stability and variability in BCR and TCR V genes with different diversity and richness metrics.
Physical biology - 1 Jun 2013
Schwartz Gregory W, Hershberg Uri
Abstract excerpt
The immune system can detect most invading pathogens. The potential for detection of pathogens is dependent on the somatic diversity of the immune repertoires. While it is known that this somatic diversity is carefully generated, it is unclear how the diversity is distributed in the different genes encoding receptors of immune cells. Utilizing different metrics for richness and diversity at the level of small...
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