Article
Insights into immune system development and function from mouse T-cell repertoires.
Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2017
Sethna Zachary, Elhanati Yuval, Dudgeon Crissy S, Callan Curtis G, Levine Arnold J, Mora Thierry, Walczak Aleksandra M
Abstract excerpt
The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors. This diversity originates in a stochastic DNA editing process (VDJ recombination) that acts on the surface receptor gene each time a new immune cell is created from a stem cell. By analyzing T-cell receptor (TCR) sequence repertoires taken from the blood and thymus of mice...
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