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Article

rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.

BMC medicine - 19 Jan 2021

Hu Yang, Sun Jing-Yi, Zhang Yan, Zhang Haihua, Gao Shan, Wang Tao, Han Zhifa, Wang Longcai, Sun Bao-Liang, Liu Guiyou

Abstract excerpt

BACKGROUND: It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer's disease (AD). However, it remains largely unclear about the role of rs1990622 variant in AD. METHODS: Here, we conducted comprehensive analyses including genetic association study, gene expression...

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Identifiers

PMID: 33461566
DOI: 10.1186/s12916-020-01883-5
PMCID: PMC7814705

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