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Article

Structural and functional characterization of the Spo11 core complex.

Nature structural & molecular biology - 1 Jan 2021

Claeys Bouuaert Corentin, Tischfield Sam E, Pu Stephen, Mimitou Eleni P, Arias-Palomo Ernesto, Berger James M, Keeney Scott

Abstract excerpt

Spo11, which makes DNA double-strand breaks (DSBs) that are essential for meiotic recombination, has long been recalcitrant to biochemical study. We provide molecular analysis of Saccharomyces cerevisiae Spo11 purified with partners Rec102, Rec104 and Ski8. Rec102 and Rec104 jointly resemble the B subunit of archaeal topoisomerase VI, with Rec104 occupying a position similar to the Top6B GHKL-type ATPase domain....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33398171
DOI: 10.1038/s41594-020-00534-w
PMCID: PMC7855791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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