Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast

doi:10.1073/pnas.2008721117

Article

Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast

12 Oct 2020

Abstract excerpt

Significance Transcription and replication of DNA create topological problems that are resolved by topoisomerases. These enzymes nick DNA strands to allow strand passage and then reseal the broken DNA to restore its integrity. Topoisomerase II (Top2) nicks complementary DNA strands to create double-strand break (DSB) intermediates that can be stabilized by chemotherapeutic drugs and are toxic if not repaired. We...

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