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Spo11: from topoisomerase VI to meiotic recombination initiator

1 Apr 2025

Abstract excerpt

Meiotic recombination is required to break up gene linkage and facilitate faithful chromosome segregation during gamete formation. By inducing DNA double-strand breaks, Spo11, a protein that is conserved in all meiotic organisms, initiates the process of recombination. Here, we chart the evolutionary history of Spo11 and compare the protein to its ancestors. Evolving from the A subunit of archaeal topoisomerase...

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PMID: 40181639
DOI: 10.1042/bst20253019

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