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TOP3A coupling with replication forks and repair of TOP3A cleavage complexes

17 Jan 2024

Abstract excerpt

Humans have two Type IA topoisomerases, topoisomerase IIIα (TOP3A) and topoisomerase IIIβ (TOP3B). In this review, we focus on the role of human TOP3A in DNA replication and highlight the recent progress made in understanding TOP3A in the context of replication. Like other topoisomerases, TOP3A acts by a reversible mechanism of cleavage and rejoining of DNA strands allowing changes in DNA topology. By cleaving...

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PMID: 38341866
DOI: 10.1080/15384101.2024.2314440

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