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Article

Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo

13 Aug 2019

Abstract excerpt

BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the level of neuronal-specific BIN1 isoform 1 protein is decreased in sporadic AD cases in parallel with neuronal loss, despite an overall increase in BIN1 total mRNA. To address the relationship between reduction of BIN1 and...

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PMID: 31408457
DOI: 10.1371/journal.pone.0220125

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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivoPMID 31408457Read ↗

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