Article

Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome

2025-03-10

Abstract excerpt

The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer’s disease (LOAD). It is expressed in neurons and glia in the brain as cell-type specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in many cell types. Previously, we reported that BIN1 predominantly localizes to presynaptic terminals in neurons and regulates presynaptic vesicular release. Ho...

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Literature Corpus work: 8fd2aadd-a6fc-57be-8abb-f87aad3c3ea2
DOI: 10.1101/2025.03.09.642169

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