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Article

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

8 Jan 2022

Abstract excerpt

The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer's disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1 (BIN1iso1) overexpression, contrary to human BIN1 isoform8 (BIN1iso8) and human BIN1 isoform9 (BIN1iso9), induced an accumulation of endosomal vesicles and neurodegeneration....

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PMID: 34998435
DOI: 10.1186/s40478-021-01285-5

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