Article

Fenofibrate Induced Cardiac Fibrosis in Mice Deficient in the Protein Quality Control Regulator, CHIP

2018-07-09

Abstract excerpt

We previously reported how the loss of CHIP expression (Carboxyl terminus of Hsc70-Interacting Protein) during pressure overload resulted in robust cardiac dysfunction, accompanied by a failure to maintain ATP levels in the face of increased energy demand. In this study, we analyzed the cardiac metabolome after seven days of pressure overload and found an increase in long- and medium-chain fatty acid metabolites i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b509f97-9d4a-5bca-8d91-56a37b29401a
DOI: 10.20944/preprints201807.0137.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fenofibrate Induced Cardiac Fibrosis in Mice Deficient in the Protein Quality Control Regulator, CHIPDOI 10.20944/preprints201807.0137.v1Read

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigeneticsSemantic proximity Read

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice.Semantic proximity Read

Molecular Profiling Reveals a Common Metabolic Signature of Tissue FibrosisSemantic proximity Read

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy.Semantic proximity Read

Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasisSemantic proximity Read

Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection FractionSemantic proximity Read

Atorvastatin Protects Against Carfilzomib-Induced Deleterious Transcriptional Changes in Human Induced Pluripotent Stem Cell-Derived CardiomyocytesSemantic proximity Read

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.Semantic proximity Read

Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEFSemantic proximity Read

High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.Semantic proximity Read

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.Semantic proximity Read

Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function.Semantic proximity Read