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Article

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy.

Molecular bioSystems - 1 Feb 2015

Gehmlich Katja, Dodd Michael S, Allwood J William, Kelly Matthew, Bellahcene Mohamed, Lad Heena V, Stockenhuber Alexander, Hooper Charlotte, Ashrafian Houman, Redwood Charles S, Carrier Lucie, Dunn Warwick B

Abstract excerpt

Energy depletion has been highlighted as an important contributor to the pathology of hypertrophic cardiomyopathy (HCM), a common inherited cardiac disease. Pharmacological reversal of energy depletion appears an attractive approach and the use of perhexiline has been proposed as it is thought to shift myocardial metabolism from fatty acid to glucose utilisation, increasing ATP production and myocardial...

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Identifiers

PMID: 25437646
DOI: 10.1039/c4mb00594e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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