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Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF

11 Apr 2025

Abstract excerpt

BACKGROUND: Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is a highly prevalent and deadly condition. Histone 3 trimethylation at lysine 36 (H3k36me3)—a chromatin signature induced by the histone methyltransferase SETD2 (SET domain containing 2)—correlates with changes in gene expression in human failing hearts; however, its role remains poorly understood. This study investigates the...

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PMID: 40211947
DOI: 10.1161/circresaha.124.325310

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