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Article

High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.

Journal of molecular and cellular cardiology - 1 Oct 2009

Li Yuquan, Cheng Lihong, Qin Qianhong, Liu Jian, Lo Woo-kuen, Brako Lowrence A, Yang Qinglin

Abstract excerpt

Peroxisome proliferator-activated receptor delta (PPARdelta) is an essential determinant of basal myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether increased lipid loading affects the PPARdelta deficient heart in transcriptional regulation of FAO and in the development of cardiac pathology. Cardiomyocyte-restricted PPARdelta knockout (CR-PPARdelta(-/-)) and control...

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Source

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Identifiers

PMID: 19595695
DOI: 10.1016/j.yjmcc.2009.07.001
PMCID: PMC2766590

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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