Article
Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice.
Cardiovascular research - 1 Jul 2018
Umbarawan Yogi, Syamsunarno Mas Rizky A A, Koitabashi Norimichi, Yamaguchi Aiko, Hanaoka Hirofumi, Hishiki Takako, Nagahata-Naito Yoshiko, Obinata Hideru, Sano Motoaki, Sunaga Hiroaki, Matsui Hiroki, Tsushima Yoshito, Suematsu Makoto, Kurabayashi Masahiko, Iso Tatsuya
Abstract excerpt
Aims: The metabolism of the failing heart is characterized by an increase in glucose uptake with reduced fatty acid (FA) oxidation. We previously found that the genetic deletion of FA-binding protein-4 and -5 [double knockout (DKO)] induces an increased myocardial reliance on glucose with decreased FA uptake in mice. However, whether this fuel switch confers functional benefit during the hypertrophic response...
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