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Article

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

1 Jul 2020

Abstract excerpt

Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models. Transcriptome analyses reveal that genes involved in fatty acid oxidation are significantly perturbed. Furthermore, mitochondrial...

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PMID: 33205063
DOI: 10.1016/j.xcrm.2020.100056

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