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Article

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

Circulation research - 22 Jan 2016

Drosatos Konstantinos, Pollak Nina M, Pol Christine J, Ntziachristos Panagiotis, Willecke Florian, Valenti Mesele-Christina, Trent Chad M, Hu Yunying, Guo Shaodong, Aifantis Iannis, Goldberg Ira J

Abstract excerpt

RATIONALE: Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)α and under normal conditions accounts for 70% of cardiac ATP content. Reduced Ppara expression during sepsis and heart failure leads to reduced fatty acid oxidation and myocardial energy deficiency. Many of the transcriptional regulators of Ppara are unknown. OBJECTIVE: To determine the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26574507
DOI: 10.1161/CIRCRESAHA.115.306383
PMCID: PMC4886555

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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