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Article

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

The Journal of clinical investigation - 1 Jan 2002

Finck Brian N, Lehman John J, Leone Teresa C, Welch Michael J, Bennett Michael J, Kovacs Attila, Han Xianlin, Gross Richard W, Kozak Ray, Lopaschuk Gary D, Kelly Daniel P

Abstract excerpt

Recent evidence has defined an important role for PPARalpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARalpha in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARalpha (MHC-PPAR) were produced and characterized. The expression of PPARalpha target genes involved in cardiac fatty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 11781357
DOI: 10.1172/JCI14080
PMCID: PMC150824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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