Article

Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection Fraction

2024-07-26

Abstract excerpt

<h4>Background</h4> Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associates with a poor outcome. Pathological gene expression in heart failure is accompanied by changes in active histone marks without major alterations in DNA methylation. Histone 3 trimethylation at lysine 36 (H3k36me3) - a chromatin signature induced by the histone methyltransferase SETD2 - stro...

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Literature Corpus work: 0130e76b-350f-59f9-8195-d22234fb65c7
DOI: 10.1101/2024.07.25.605217

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