Article

Atorvastatin Protects Against Carfilzomib-Induced Deleterious Transcriptional Changes in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

2025-12-23

Abstract excerpt

The mechanisms underlying carfilzomib (CFZ)-induced cardiotoxicity remain incompletely elucidated. In this study, we used human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) to char-acterize the transcriptional impact of CFZ and to evaluate whether atorvastatin could prevent these dele-terious transcriptional changes. hiPSC-CMs were treated with 1 µM CFZ, CFZ + atorvastatin, atorvastatin, or veh...

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Literature Corpus work: 9d3ac945-4a93-5483-9dec-9e58acf0b317
DOI: 10.20944/preprints202512.2070.v1

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