Article

Applying high-resolution spatial transcriptomics to characterize the amyloid plaque cell niche in Alzheimer’s Disease

2023-07-01

Abstract excerpt

The amyloid plaque cell niche is a pivotal hallmark of Alzheimer’s disease (AD). Where early spatial transcriptomics (ST) technologies have provided valuable information on transcriptomic alterations in the small tissue domains overlaying with amyloid plaques, they lacked cellular resolution. Here we compare two novel high-resolution ST platforms, CosMx and Stereo-seq, in their ability to characterize the cellular...

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Literature Corpus work: 7b138d2b-cce8-565f-b62e-79466746928a
DOI: 10.1101/2023.06.29.546675

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