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Uncovering Plaque-Glia Niches in Human Alzheimer’s Disease Brains Using Spatial Transcriptomics

2024-09-10

Abstract excerpt

Amyloid-beta (Aβ) plaques and surrounding glial activation are prominent histopathological hallmarks of Alzheimer’s Disease (AD). However, it is unclear how Aβ plaques interact with surrounding glial cells in the human brain. Here, we applied spatial transcriptomics (ST) and immunohistochemistry (IHC) for Aβ, GFAP, and IBA1 to acquire data from 258,987 ST spots within 78 postmortem brain sections of 21 individuals...

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Literature Corpus work
f6b44fda-a371-5793-9737-5730936cf8b1
DOI
10.1101/2024.09.05.611566
Open publication

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Uncovering Plaque-Glia Niches in Human Alzheimer’s Disease Brains Using Spatial TranscriptomicsDOI 10.1101/2024.09.05.611566
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