Article

Integrative mapping of spatial transcriptomic and amyloid pathology in Alzheimer’s disease at single-cell resolution

2023-05-07

Abstract excerpt

Alzheimer’s disease (AD) is a complex neurodegenerative disorder that affects millions of people worldwide. Despite decades of research, the underlying molecular and cellular changes of AD remain unresolved, especially in terms of the spatial structure of gene expression changes that correlates with pathology, e.g. amyloid beta (A-beta) plaques. Recent advances in imaging-or sequencing-based single-cell spatial tr...

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Literature Corpus work: 77e2c790-a7d6-5367-af44-e37f9307898d
DOI: 10.1101/2023.05.07.539389

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