Article

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer’s Disease (AD)

2025-08-02

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of dementia affecting 55 million people worldwide. The pathological hallmarks of AD, beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFT), follow distinct stereotypical patterns of progression across brain regions and trigger a multicellular response that ultimately leads to neuronal loss and cognitive decline. Despite the uniform spread of Aβ plaque across the...

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Literature Corpus work: 6328ce91-8e88-52e4-a748-eb159bfb413d
DOI: 10.1101/2025.07.31.667719

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