Article

PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

2023-08-23

Abstract excerpt

<title>Abstract</title> <p>Background Microtubule-binding protein tau is a misfolding-prone protein associated with tauopathies. As tau undergoes cell-to-cell transmission, extracellular tau aggregates convert astrocytes into a pro-inflammatory state via integrin activation, causing them to release unknown neurotoxic factors. Results Here, we combine transcriptomics with isotope labeling-based quantitative mass...

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Literature Corpus work: 7af7dd35-1932-558c-914c-99cb10157f81
DOI: 10.21203/rs.3.rs-3253118/v1

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