Article

Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

2018-09-14

Abstract excerpt

<h4>SUMMARY</h4> The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. Tau secretion from neurons is the first step in tau transmission, but little is known about the cellular mechanism. Here, we report that p300/CBP, the lysine acetyltransferase that acetylates tau and regulates its homeostasis and toxicity, serves as a key regulator of tau secretion by i...

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Literature Corpus work: 31a7c15e-1123-5716-bbdb-5126164638d9
DOI: 10.1101/418640

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