Article

Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology

2026-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Immunoproteasome induction is prominent in Alzheimer’s disease (AD), but whether it protects proteostasis or amplifies neuroinflammation remains unresolved. Here, we generated immunoproteasome-deficient PS19 tauopathy and APP/human tau double-knock-in mice by crossing each disease model with L7M1 mice lacking two immunoproteasome catalytic subunits. Immunoproteasome deficiency increased phospho-...

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Literature Corpus work: 3a11775a-3fba-5500-9f70-35a14fb9696f
DOI: 10.64898/2026.07.14.738427

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