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Relevance of host tau in tau seeding and spreading in tauopathies

9 Aug 2019

Abstract excerpt

Human tau seeding and spreading occur following intracerebral inoculation of brain homogenates obtained from tauopathies in transgenic mice expressing natural or mutant tau, and in wild-type (WT) mice. The present study was geared to learning about the patterns of tau seeding, the cells involved and the characteristics of tau following intracerebral inoculation of homogenates from primary age-related tauopathy...

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PMID: 31397930
DOI: 10.1111/bpa.12778

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