Article

GLaMST: Grow Lineages along Minimum Spanning Tree for B Cell Receptor Sequencing Data

2018-11-08

Abstract excerpt

B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens. Lineage trees are used to describe this microevolution of B cell immunoglobulin genes. In a lineage tree, each node is one BCR sequence that mutated from the germinal center and each directed edge...

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Literature Corpus work: 7acd6cab-ab0c-50e7-88ee-558a7bc687c5
DOI: 10.1101/465476

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