Article

SeQuoIA: a single-cell BCR sequencing analysis pipeline for tracking selection mechanisms in germinal centres

2025-02-17

Abstract excerpt

Germinal centres (GCs) are specialized structures where B cells undergo iterative steps of B-cell receptor (BCR) somatic hypermutation and selection of best antigen binders in a darwinian-like fashion. The accelerated evolutionary process leads to the production of high-affinity antibodies that are crucial for robust and long-term humoral immunity. Within this frame, single-cell BCR sequencing analysis is a method...

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Literature Corpus work: 98e0e2ed-7bca-5703-a12f-a1367a5ccec6
DOI: 10.1101/2025.02.13.638132

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