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Article

GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data.

BMC genomics - 9 Sept 2020

Yang Xingyu, Tipton Christopher M, Woodruff Matthew C, Zhou Enlu, Lee F Eun-Hyung, Sanz Inãki, Qiu Peng

Abstract excerpt

BACKGROUND: B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens. Lineage trees are used to describe this microevolution of B cell immunoglobulin genes. In a lineage tree, each node is one BCR sequence that mutated from the germinal center and each...

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Identifiers

PMID: 32900378
DOI: 10.1186/s12864-020-06936-w
PMCID: PMC7488003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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