Article
Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances.
BMC bioinformatics - 27 Feb 2023
Abdollahi Nika, Jeusset Lucile, de Septenville Anne, Davi Frederic, Bernardes Juliana Silva
Abstract excerpt
B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated ancestor and mutated variants. In a B cell lineage, cells with a higher antigen affinity will undergo clonal...
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