Article

Reconstructing the evolutionary history of a B cell lineage with minimum spanning tree and genotype abundances

2022-10-18

Abstract excerpt

B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated ancestor and mutated variants. In a B cell lineage, cells with a higher antigen affinity will undergo clonal expansion...

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Literature Corpus work: 33a51921-3c4e-519d-a54d-ee22622253ca
DOI: 10.21203/rs.3.rs-2134434/v1

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