Article

Inferring B cell phylogenies from paired heavy and light chain BCR sequences with Dowser

2023-10-02

Abstract excerpt

Antibodies are vital to human immune responses and are composed of genetically variable heavy and light chains. These structures are initially expressed as B cell receptors (BCRs). BCR diversity is shaped through somatic hypermutation and selection during immune responses. This evolutionary process produces B cell clones, cells that descend from a common ancestor but differ by mutations. Phylogenetic trees inferre...

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Literature Corpus work: 26d29757-985c-5bca-82b0-49d4c3c5712c
DOI: 10.1101/2023.09.29.560187

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