Article

Reconstructing the evolutionary history of a B cell lineage with minimum spanning tree and genotype abundances

2022-03-01

Abstract excerpt

B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated ancestor and mutated variants. In a B cell lineage, cells with a higher antigen affinity will undergo clonal expansion...

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Literature Corpus work: e8195d96-b40a-5603-b07f-89a5dc1ac580
DOI: 10.1101/2022.02.27.481992

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