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Ancestra: A lineage-explicit simulator for benchmarking B-cell receptor repertoire and lineage inference methods

2026-04-21

Abstract excerpt

<h4> A bstract </h4> High-throughput B-cell receptor sequencing has transformed the analysis of adaptive immunity, but benchmarking clonal grouping and lineage reconstruction methods remains limited by the absence of datasets with known evolutionary histories. Here we present Ancestra, a lineage-explicit simulator of B-cell receptor heavy-chain affinity maturation. Ancestra models stochastic V(D)J recombination...

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Literature Corpus work: cc80a25e-6142-51fc-99a0-05c9d092beef
DOI: 10.64898/2026.04.17.718988

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