Transposable element-host genome evolutionary arms race revealed by multi-modal epigenomic profiling in a telomere-to-telomere human genome reference

Abstract excerpt

ABSTRACT For a quarter of a century transposable elements have been recognized as a major component of the human genome, comprising 46.1% according to recent estimates, and as key drivers of regulatory innovation as well as participants in an ongoing evolutionary arms race with host defense systems. Using the newly released T2T ENCODE dataset, we quantified the epigenetic impact of 3.7 million transposable element...

Topics

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• Chromosomal and Genetic Variations
• Genomics and Chromatin Dynamics
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

990643b3-657c-53da-9687-c2db5582dfee

DOI

10.1098/rsos.260639