Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome

Abstract excerpt

Repetitive elements insertions (REIs), including tandem repeat insertions (TRIs) and transposable element insertions (TEIs), constitute >90% of large-scale (>50bp) somatic insertions and are linked to diseases and cancer biomarkers. However, the genomic landscape of large-scale REIs in pan-cancer has not been well-characterized due to short-read sequencing limitations. Here, we detected somatic REIs in 325 cancer...

Topics

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• Genes, Neoplasm
• Glioblastoma
• Long Interspersed Nucleotide Elements
• Microsatellite Instability
• Molecular Sequence Annotation
• Multiple Myeloma
• Mutagenesis, Insertional
• Retroelements

Identifiers and source

Literature Corpus work

de4645ef-c408-55a6-a46c-9c95775dad14

DOI

10.1101/2025.02.19.638966