Article

EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints

2024-05-24

Abstract excerpt

Polygenic risk score (PRS) prediction of complex diseases can be improved by leveraging related phenotypes. This has motivated the development of several multi-trait PRS methods that jointly model information from genetically correlated traits. However, these methods do not account for vertical pleiotropy between traits, in which one trait acts as a mediator for another. Here, we introduce endoPRS, a weighted lass...

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Literature Corpus work: 7a6b7511-71ce-540a-b2a3-0ecb2a398580
DOI: 10.1101/2024.05.23.24307839

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