Article
Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models.
Human molecular genetics - 15 Jul 2015
Spiliopoulou Athina, Nagy Reka, Bermingham Mairead L, Huffman Jennifer E, Hayward Caroline, Vitart Veronique, Rudan Igor, Campbell Harry, Wright Alan F, Wilson James F, Pong-Wong Ricardo, Agakov Felix, Navarro Pau, Haley Chris S
Abstract excerpt
We explore the prediction of individuals' phenotypes for complex traits using genomic data. We compare several widely used prediction models, including Ridge Regression, LASSO and Elastic Nets estimated from cohort data, and polygenic risk scores constructed using published summary statistics from genome-wide association meta-analyses (GWAMA). We evaluate the interplay between relatedness, trait architecture and...
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