Article
Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways.
The European respiratory journal - 1 Aug 2024
Stikker Bernard, Trap Lianne, Sedaghati-Khayat Bahar, de Bruijn Marjolein J W, van Ijcken Wilfred F J, de Roos Emmely, Ikram Arfan, Hendriks Rudi W, Brusselle Guy, van Rooij Jeroen, Stadhouders Ralph
Abstract excerpt
BACKGROUND: Individual differences in susceptibility to developing asthma, a heterogeneous chronic inflammatory lung disease, are poorly understood. Whether genetics can predict asthma risk and how genetic variants modulate the complex pathophysiology of asthma are still debated. AIM: To build polygenic risk scores for asthma risk prediction and epigenomically link predictive genetic variants to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.